Seth B. Taube on the Future of Treatment: A Conversation about Mental Health

Mental health issues have become a growing concern worldwide, with depression, stress, anxiety, and chronic loneliness rising. These conditions have significant impacts on individuals, families, and society as a whole. However, cutting-edge research using psychedelics like psilocybin, MDMA, and ketamine offers new hope for treating these conditions.

Depression-Mental Health

Depression affects around 264 million people worldwide and is the leading cause of disability. In the United States, one in six adults experiences depression. Stress is also a significant concern, with 77% of Americans experiencing physical symptoms of stress and 73% experiencing psychological symptoms. Anxiety disorders are the most common mental illness in the United States, affecting 40 million adults. Chronic loneliness is also a growing concern, with 61% of adults in the United States reporting feeling lonely.

The impact of these conditions on society is significant, with depression and anxiety costing the global economy $1 trillion each year in lost productivity. Mental health conditions in the United States are responsible for $193.2 billion in lost earnings per year. Mental health conditions can also lead to family conflict and disruption, substance abuse, homelessness, and suicide.

Traditional Treatments

However, traditional treatments like talk therapy and medication are not always effective for everyone. This is where cutting-edge research using psychedelics like psilocybin, MDMA, and ketamine offers new hope.
Psilocybin is a psychedelic compound found in certain species of mushrooms. Studies have shown it has therapeutic potential for depression, anxiety, and addiction.

The Imperial College London recently conducted a study that found psilocybin therapy effective in treating depression, with 47% of participants experiencing remission after one week and 42% still remission after three months. Another study by the Johns Hopkins Center for Psychedelic and Consciousness Research found that psilocybin therapy effectively reduced anxiety and depression in cancer patients.

MDMA-Mental Health

MDMA is a synthetic compound used recreationally as a party drug. However, it is currently being studied as a potential treatment for PTSD. A study by the Multidisciplinary Association for Psychedelic Studies (MAPS) found that MDMA-assisted therapy effectively treated PTSD, with 68% of participants no longer meeting the criteria for PTSD after three sessions.

Ketamine is an anaesthetic drug used for decades in surgical settings. However, it is currently being studied as a potential treatment for depression. A recent meta-analysis of 28 studies found that ketamine was effective in reducing symptoms of depression in both the short and long term.

While the use of psychedelics in mental health treatment is still in the early stages of research, the results are promising. These compounds have the potential to offer new and effective treatments for mental health conditions that do not respond to traditional therapies. They may also provide a new approach to mental health treatment that focuses on addressing the root causes of these conditions rather than just managing symptoms.


Seth Taube